Bachelor of Pharmacy Syllabus

Semester III

  • COURSE CODE
    COURSE NAME
    CREDITS
  • JBP-301

    Pharmaceutical Analysis – II:

    UNIT-I

    Theoretical considerations and application in drug analysis and quality control by the following analytical techniques (assays included in the Indian Pharmacopoeia 1996).

    • • Non-Aqueous Titration.
    • • Complexometric Titration.

    UNIT-II

    Miscellaneous methods of analysis:

    Diazotization titrations, Kjeldahl method of Nitrogen estimation, Karl- Fischer titration. Radioassays. Alcohol estimation in galenicals.

    UNIT-III

    Electro Chemistry – Introduction, Dielectric cell, electrode potential, Nernst equation, salt bridge, standard potential, reference and indicator electrodes, measuring the relative voltage of cell.

    • • Potentiometry: General principles, instrumentation and applications.
    • • Conductometry: General Principles, instrumentation and applications.

    UNIT-IV

    Principle, instrumentation and pharmaceutical applications, Paper Chromatography, column chromatography, TLC.

    UNIT-V

    Basic Principles, Instrumentation and Applications of GLC & HPLC.

    Books:

    • 1. Beckett, A.H. & Stenlake J.B, Practical Pharmaceutical Chemistry, Vol, I and II, The Athlone Press of the University of London.
    • 2. Pharmacopoeia of India, published by The Controller of Publications, Delhi.
    • 3. British Pharmacopoeia, Her Majesty's Stationary Office, University Press, Cambridge.
    • 4. Connors K.A., A Textbook of Pharmaceutical Analysis, Wiley Interscience, New York.
    04
  • JBP-302

    Pharmaceutical Chemistry – IV (Organic Chemistry - II):

    UNIT-I

    ά, β- Unsaturated carbonyl compounds, cycloaddition. Compounds containing active methylene group and their synthetic importance- Acetoacetic ester and malonic ester. Polynuclear hydrocarbons-Napthalene, anthracene and phenantherene.

    UNIT-II

    Heterocyclic Compound – Nomenclature, Chemistry, preparation, properties and pharmaceutical importance of pyrrole, furan, thiophen, pyridine, pyrimidine, imidazole, pyrazole, thiazole, benzimidazole, indole, phenothiazine.

    UNIT-III

    Name reactions – Definition, reaction mechanism and synthetic application of Merwin –Pondorff,Verley reduction, Oppeneaur oxidation, Bechmann rearrangement, Mannich reaction, Diel's alderreaction, Michel, Reformatsky, Knoevanegal reaction, Benzoin condensation. Connizaro, witting,fries, sandmear and bechmann.

    UNIT-IV

    Classification, structure, reactions, structure elucidation, identification of Carbohydrates: Monosaccharide – Glucose and fructose, Disaccharides – Sucrose, lactose and maltose, Polysaccharides–Starch.

    UNIT-V

    Classification, identification, general methods of preparation and reactions of amino acids andproteins. Structure of Nucleic Acids. Chemistry & identification of oils, fats and waxes.

    Books:

    • 1. Mann P.G. & Saunders B.C., Practical Organic Chemistry, ELBS/ Longman, London.
    • 2. Furniss B.S., Hannaford A.J., Smith P.W.G., and Tatehell A.R., Vogel's Textbook of PracticalOrganic Chemistry, The ELBS/ Longman, London.
    • 3. Morrison, T.R. & Boyd, R.N., Organic Chemistry, Prentice Hall of India, Private Limited, NewDelhi.
    • 4. Finar, I.L., Organic ChemistryVol. I & II, ELBS/Longman.
    • 5. Jain, M.K. & Sharma S.C., Organic Chemistry, ShobanLalNagin Chand & Co., Delhi.
    04
  • JBP-303

    Pharmacognosy– II:

    UNIT-I

    Resins: Study of Drugs Containing Resins and Resin Combination like Colophony, podophyllum, jalap, cannabis, capsicum, myrrh, asafoetida, balsam of tolu, balsam of peru, benzoin, turmeric, ginger.

    UNIT-II

    Tannins: Study of tannins and tannin containing drugs like Gambier, black catechu, gall and myrobalan.

    UNIT-III

    Volatile Oils : General methods of obtaining volatile oils from plants, Study of volatile oils of Mentha, Coriander, Cinnamon, Cassia, Lemon peel, Orange peel, Lemon grass, Citronella, Caraway, Dill, Spearmint, Clove, Fennel, Nutmeg, Eucalyptus, Chenopodium, Cardamom, Valerian, Musk, Palmarosa, Gaultheria, Sandal wood.

    UNIT-IV

    Phytochemical Screening:

    • a. Preparation of extracts.
    • b. Screening of alkaloids, saponins, cardenolides and bufadienolides, flavonoids and leucoanthocyanidins, tannins and polyphenols, anthraquinones, cynogenetic glycosides, amino acids in plant extracts.

    UNIT-V

    Fibres: Study of fibres used in pharmacy such as c0tton, silk, wool, nylon, glass-wool, polyester and asbestos. Pharmaceutical aids: Study of pharmaceutical aids like talc, diatomite, kaolin, bentonite, gelatin and natural colors

    Books:

    • 1. Trease G.E., & Evans W.C., Pharmacognosy, BalliereTindall East Bourne U.K.
    • 2. Tyler V.E. et al, Pharmacognosy, Lea & febiger, Philadelphia.
    • 3. Wallis, T.E., Text Book of Pharmacognosy, J & A Churchill Ltd, London.
    • 4. Kokate C.K. et al, Pharmacognosy, NiraliPrakashan, Pune.
    04
  • JBP-304

    Pharmaceutics –II (Unit Operations-I):

    UNIT-I

    Unit Operations:Introduction, Fluid Flow: Types of flow, Reynolds's number, Viscosity, basic situations of fluid flow, valves, flow meters, manometers and measurement of flow and pressure.

    UNIT-II

    Water systems: Purified Water, water for injection, Sterile water for injection, quality requirementand treatment of water. Cleaning of premises and standardization of cleaning. Filtration and Centrifugation:Theory of filtration, filter aids, filter media, industrial filters specially filter press, rotary filter. Factors affecting filtration, Principles of centrifugation, industrial centrifugal filters, and centrifugal sedimenters.

    UNIT-III

    Crystallization:Characteristics of crystals, Solubility curves and calculation of yields. Material andheat balances around Swenson Walker Crystallizer. Super-saturation theory and its limitations, Nucleation mechanisms, crystal growth, Study of various types of Crystallizer, Tanks, agitated batch,Swenson Walker, Single vacuum, circulating magma and Krystal crystallizer, Caking of crystals andits prevention.

    UNIT-IV

    Heating, Ventilation & AC Systems:Basic concepts and definition, wet bulb and adiabatic saturation temperatures, Psychometric chart and measurement of humidity, application of humiditymeasurement in pharmacy, equipment for dehumidification operations. Principles and applications ofrefrigeration and air conditioning.

    UNIT-V

    Material of Construction:General study of composition, Properties and applications of the materials of construction. Industrial Hazards and Safety Precautions:Mechanical, Chemical, Electrical, fire and Dust hazards.

    Books:

    • 1. Badger W.L. &Banchero J.T., Introduction to Chemical Engineering, McGraw Hill International Book Co., London.
    • 2. Perry R.H. & Chilton C.H., Chemical Engineers Handbook, McGraw Kogakusha Ltd.
    • 3. McCabe W.L. & Smith J.C., Unit Operation of Chemical Engineering, McGraw Hill International Book Co., London.
    • 4. Sambhamurthy, Pharmaceutical Engineering, New Age Publishers.
    • 5. Gavhane, K.A., Unit Operation-I, Nirali Prakashan.
    04
  • JBP-305

    Anatomy, Physiology and Health Education-II (APHE -II):

    UNIT-I

    Digestive System: Gross anatomy of the gastro-intestinal tract, functions of its different parts including those of liver, pancreas and gall bladder, various gastrointestinal secretions and their role in the absorption and digestion of food. Disorders of digestive system.

    UNIT-II

    Respiratory System: Anatomy of respiratory organs & its functions, respiration, mechanism and regulation of respiration, respiratory volumes and vital capacity.

    UNIT-III

    Central Nervous System: Functions of different parts of brain and spinal cord. Neurohumoral transmission in the central nervous system, reflex action electroencephalogram, specialized functions of the brain, Cranial nerves and their functions. Autonomic Nervous System: Physiology and functions of the autonomic nervous system. Mechanism of neurohumoral transmission in the A.N.S.

    UNIT-IV

    Endocrine System: Basic anatomy and physiology of Pituitary, Thyroid, Parathyroid. Adrenals, Pancreas, Testes and ovary, their hormones and functions. Sense Organs: Basic anatomy and physiology of the eye (vision), ear (hearing), taste buds, nose (smell) and skin (superficial receptors).

    UNIT-V

    Concepts of health and disease: Disease causing agents and prevention of disease. Classification of food requirements: Balanced diet, nutritional deficiency disorders, their treatment and prevention, specifications for drinking water. Demography and family planning: Medical termination of pregnancy. Communicable diseases: Brief outline, their causative agents, modes of transmission and prevention (Chicken pox, measles, influenza, diphtheria, whooping cough, tuberculosis, poliomyelitis, helminthiasis, malaria, filariasis, rabies, trachoma, tetanus, leprosy, syphilis, gonorrhoea, and AIDS). First Aid: Emergency treatment of shock, snake bites, burns, poisoning, fractures and resuscitation methods.

    Books:

    • 1. Robbins S.L., Kumar V., Basic Pathology, WB Saunders.
    • 2. Chaurasia B.D., Human Anatomy, Regional & AppliedPart I, II & III, CBS Publishers & Distributors, New Delhi.
    • 3. Guyton A.C., Hall J.E., Text book of Medical Physiology, WB Saunders Company.
    • 4. Chatterjee C.C., Human Physiology, Medical Allied Agency, Calcutta.
    • 5. Ross & Wilson, Anatomy & Physiology in Health & Illness, Churchill Livingstone.
    • 6. Tortora G.J., & Anagnodokos N.P., Principles of Anatomy & Physiology, Harper & Rave Publishers, New Delhi.
    • 7. Dipiro J.L., Pharmacotherapy – A Pathophysiological Approach, Elsevier.
    04
  • JBP-351

    Pharmaceutics –II (Unit Operations-I) (P):

    • 1. Measurement of flow of fluids and their pressure, determination Reynold's number and calculation of Frictional losses.
    • 2. Evaluation of filter media, determination of rate of filtration and study of factors affecting filtration.
    • 3. Experiments to demonstrate applications of centrifugation.
    • 4. Thermometers and Psychrometric charts.
    • 5. Determination of humidity - use of Dry Bulb and Wet Bulb.
    02
  • JBP-352

    Pharmaceutical Chemistry – IV (Organic Chemistry - II) (P):

    At least five exercises in synthesis involving various heterocyclic ring systems. An exercise involving stereo-selective synthesis of a compound. Resolution of racemic DL-alanine or any other example. Workshop on molecular modelling of primary, secondary and tertiary structures of proteins, molecular modelling on double helical structure of nucleic acid showing hydrogen bonding.

    02
  • JBP-353

    Pharmacognosy– II (P):

    • 1. Identification of crude drugs mentioned in theory.
    • 2. Study of fibres and pharmaceutical aids.
    • 3. Microscopic studies of seven-selected crude drugs and their powders mentioned under the category of volatile oils in theory and their chemical tests,
    • 4. General chemical tests for alkaloids, glycosides, steroids, flavonoids and tannins.
    02
  • JBP-354

    Pharmaceutical Analysis – II (P):

    • 1. Non-aqueous Titrations: Preparation and standardization of perchloric acid and sodium/potassium/lithium methoxides solutions; Estimations of some pharmacopoeial products.
    • 2. Complexometric Titrations: Preparations and standardization of EDT A solution, some exercises related to pharmacopoeial assays by complexometric titrations.
    • 3. Miscellaneous Determinations: Exercises involving diazotisation, Kjeldahl, Karl-Fischer, Oxygen flask combustion and gasometry methods. Determination of alcohol content in liquid galenicals, procedure (BPC) shall be covered.
    • 4. Determination of acid base dissociation constants and plotting of titration curves using pH meter.
    • 5. Exercises involving conductometric titrations.
    • 6. Exercises based on paper, column and thin- layer chromatography.
    02
  • JBP-355

    Anatomy, Physiology and Health Education-II (APHE -II) (P):

    • 1. Estimation of haemoglobin in blood. Determination of bleeding time, clotting time, R.B.C. Count, Total leucocyte count, D.L.C. and E.S.R.
    • 2. Recording of body temperature, pulse rate and blood pressure.
    • 3. Basic understanding of Electrocardiogram-PQRST waves and their significance.
    02
  • Total Credits
     
    30