Bachelor of Pharmacy Syllabus

Semester VI

  • COURSE CODE
    COURSE NAME
    CREDITS
  • JBP-601

    Pharmaceutical Chemistry – VI (Medicinal Chemistry-I):

    UNIT-I

    Basic Principles of Medicinal Chemistry: Physico-chemical aspects (Optical, geometric and bioisosterism) of drug molecules and bilological action, Drug-receptor interaction including transduction mechanisms.

    UNIT-II

    Principles of Drug Design (Theoretical Aspects): Traditional analog (QSAR) and mechanism based approaches (Introduction 00' graph theory, applications of quantum mechanics, Computer Aided Drug Desigming (CADD) androolecular modeling.

    UNIT-III

    Synthetic procedures of selected drugs, mode of action, uses, structure activity relationship including physicochemical properties of the following classes of drugs:

    • A.Drugs acting at Synaptic and neuro-effector junction sites:
      • i. Cholinergics and Anticholinesterases
      • ii. Adrenergic .drugs
      • iii. Antispasmodic and anti-ulcer drugs
      • iv. Neuromuscular blocking agents.

    UNIT-IV

    • Autocoids
      • i. Antihistamines ii. Eicosanoids
      • iii. Analgesic-antipyretics, anti-inflammatory (non-steroidal) agents.

    UNIT-V

    Drugs affecting uterine motility Oxytocics (including oxytocin, ergot alkaloids and prostaglandins' Biochemical approaches in drug designing wherever applicable should be discussed.

    Books:

    • 1. Mann P.G. & Saunders B.C., Practical Organic Chemistry, ELBS/Longman, London.
    • 2. Furniss B.A., Hannaford A.J., Smith P.W.G. and Tatehell A.R., Vogel's Textbook of PracticalOrganic Chemistry, The ELBS/ Longman, London.
    • 3. Pharmacopoeia of India, Minsitry of Health, Govt. of India.
    • 4. Wolff, Burger's Medicinal Chemistry, John Wiley & Sons, New York.
    • 5. Nogrady T., Medicinal Chemistry – A Biochemical Approach, Oxford University Press, NewYork
    • 6. Foye W.C., Principles of Medicinal Chemistry, Lea &Febiger, Philadelphia.
    • 7. Singh Harkrishan and Kapoor V.K., Organic Pharmaceutical Chemistry, Vallabh Prakashan,Delhi
    04
  • JBP-602

    Pharmacology – II:

    UNIT-I

    Pharmacology of Cardiovascular System:

    • a. Digitalis and cardiac glycosides.
    • b. Antihypertensive drugs.
    • c. Antianginal and Vasodilator drugs, including calcium channel blockers and beta adrenergic antagonists.
    • d. Antiarrhythmic drugs
    • e. Antihyperlipedemic drugs
    • f. Drugs used in the therapy of shock.

    UNIT-II

    Drugs Acting on the Hemopoietic System:

    • a. Hematinics.
    • b. Anticoagulants, Vitamin K and hemostatic agents.
    • c. Fibrinolytic and anti-platelet drugs.
    • d. Blood and plasma volume expanders.

    UNIT-III

    Drugs acting on urinary system:

    • a. Fluid and electrolyte balance
    • b. Diuretics

    UNIT-IV

    Autocoids:

    • a. Histamine, 5-HT and their antagonists.
    • b. Prostaglandins, thromboxanes and leukotrienes.
    • c. Pentagastrin, Cholecystokinin, Angiotensin, Bradykinin and Substance P.

    UNIT-V

    Drugs Acting on the Respiratory System:

    • a. Anti-asthmatic drugs including bronchodilators.
    • b. Anti-tussives and expectorants.
    • c. Respiratory stimulants.

    Books:

    • 1. Rang M.P., Date M.M., Riter J.M., Pharmacology, Churchill Livingstone.
    • 2. Katzung, B.G., Basic & Clinical Pharmacology, Prentice Hall, International.
    • 3. Craig, C.R. & Stitzel R.R., Modern Pharmacology, Little Brown and Co., 1994.
    • 4. Barar F.S.K., Text Book of Pharmacology, Interprint, New Delhi.
    • 5. Goodman & Gilman, The Pharmacological basis of Therapeutics, Editors:-J.G. Hardman, L.E. Limbird, P.B. Molinoss, R.W. Ruddon& A.G. Gil, Pergamon Press.
    • 6. Satoskar & Bhandarkar, Pharmacology & Pharmacotherapeutics, Popular Prakashan Pvt. Ltd.,Bombay.
    • 7. Laurence D.R. & Bannet P.N., Clinical Pharmacology, Churchill Livingstone.
    • 8. Tripathi K.D., Essentials of Medical Pharmacology, Jay Pee Publishers, New Delhi.
    04
  • JBP-603

    Pharmacognosy–V (Chemistry of Natural Products):

    UNIT-I

    Chemical and spectral approaches to simple molecules of natural origin Concept of stereoisomerism taking examples of natural products. Chemistry, biogenesis and pharmacological activity of medicinally important monoterpenes, sesquiterpenes, diterpenes, and triterpenoids.

    UNIT-II

    Carotenoids:α-carotenoids, β-carotenes, vitamin A, Xanthophylls of medicinal importance.

    UNIT-III

    Glycosides: Chemistry and biosynthesis of digitoxin, digoxin, hecogenin, sennosides, diosgenin and sarasapogenin. Alkaloids: Chemistry, biogenesis and pharmacological activity of atropine and related compounds; quinine, reserpine, morphine, papaverine, ephedrine, ergot and vinca alkaloids.

    UNIT-IV

    Chemistry and biogenesis of medicinally important lignans and quassanoids, flavonoids

    UNIT-V

    Chemistry and therapeutic activity of penicillin, streptomycin and tetracyclines.

    Books:

    • 1. Tyler V.E., et.al. , Pharmacognosy, Lea & Febiger Philadelphia.
    • 2. Kokate, C.K., Pharmacognosy, NiraliPrakashan, Pune.
    • 3. Trease G.E. & Evan, W.C., Pharmacognosy, BailleireTindall East Bourne, U.K.
    • 4. Stahl E., Thin Layer Chromatography, A Laboratory Hand Book, Springer Verlag, Berlin.
    • 5. Harborne, J.B. Phytochemical Methods, Chapman & Hall, International Ed, London.
    • 6. Pharmacopoeia of India.
    • 7. Finar I.L., Organic Chemistry, Vol. I & II ELBS, London.
    • 8. Agarwal O.P., Chemistry of Organic Natural Product, Vol. I & II Goel Pub. House, Meerut.
    04
  • JBP-604

    Pharmaceutics–VII (Pharmaceutical Technology II):

    UNIT-I

    Capsules: Advantages and disadvantages of capsule dosage form, material for production of hard gelatin capsules, size of capsules, method of capsule filling, soft gelatin, capsule shell and capsule content, importance of base absorption and minimum/gm factors in soft capsules, quality control, stability testing and storage of capsule dosage forms. 2. Micro-encapsulation: Types of microcapsules, importance of microencapsulation in pharmacy, microencapsulation by phase separation, coacervation, multi orifice, spray drying, spray congealing, polymerisation complex emulsion, air suspension technique, coating pan and other techniques, evaluation of micro capsules.

    UNIT-II

    Tablets:

    • a. Formulation of different types of tablets, granulation, technology on large-scale by various techniques, physics of tablets making, different types of tablet compression machinery and the equipments employed, evaluation of tablets.
    • b. Coating of Tablets: Types of coating, film forming materials, formulation of coating solution, equipments for coating, coating process, evaluation of coated tablets.
    • c. Stability kinetics and quality assurance.

    UNIT-III

    Parenteral Products:

    • a. Preformulation factors, routes of administration, water for injection, pyrogenicity, non aqueous vehicles, isotonicity and methods of its adjustment
    • b. Formulation details, containers and closures and selection.
    • c. Prefilling treatment, washing of containers and closures, preparation of solution and suspensions, filling and
    • closing of ampoules, vials, infusion fluids, lyophillization& preparation of sterile powders, equipment for large scale manufacture and evaluation of parenteral products.
    • d. Aseptic Techniques-source of contamination and methods of prevention, Design of aseptic area, Laminar flow bench services and maintenance.
    • e. Sterility testing of pharmaceuticals.

    UNIT-IV

    Surgical products: Definition, primary wound dressing, absorbents, surgical cotton, surgical gauzes etc., bandages, adhesive tape, protective cellulosic hemostastics, official dressings, absorbable and nonabsorbable sutures, ligatures and catguts. Medical prosthetics and organ replacement materials.

    UNIT-V

    Packaging of Pharmaceutical Products: Packaging components, types, specifications and methods of evaluation, stability aspects of packaging. Packaging equipments, factors influencing choice of containers, legal and other official requirements for containers, package testing.

    Books:

    • 1. Remington: The Science and Practice of Pharmacy Pharmaceutical Sciences Vol. I & III, Mack Publishing Company, U.S.A.
    • 2. Avis R.E., Pharmaceutical Dosage Forms: Parenteral Medication, Vol-I, Marcel Dekker-Inc, New York & Basel.3. Ansel H.C., Introduction to Pharmaceutical Dosage Forms, Lea & Febiger, Philadelphia, U.S.A.
    • 4. Juliano R.C., Drug Delivery Systems, Oxford University Press, Oxford.
    • 5. Herbert A. Liebermann & Leon Lachman, Theory & Practice of Industrial Pharmacy, Lea Febiger, Philadelphia, U.S.A.
    04
  • JBP-605

    Pharmaceutical Jurisprudence & Ethics:

    UNIT-I

    Introduction

    • a. Pharmaceutical Legislations - A brief review.
    • b. Drugs & Pharmaceutical Industry - A brief review.
    • c. Pharmaceutical Education - A briefreview.

    UNIT-II

    An elaborate study of the following

    • a. Pharmaceutical Ethics
    • b. Pharmacy Act 1948.
    • c. Drugs and Cosmetics Act 1940 and Rules 1945.
    • d. Medicinal & Toilet Preparations (Excise Duties) Act 1955.
    • e. Narcotic Drugs & Psychotropic Substances Act 1985 & Rules.
    • f. Drugs Price Control Order.

    UNIT-III

    A brief study of the following with special reference to the main provisions.

    • a. Poisons Act 1919
    • b. Drugs and Magic Remedies (Objectionable Advertisements) Act 1954
    • c. Medical Termination of Pregnancy Act 1970 & Rules 1975.
    • d. Prevention of Cruelty to Animals Act 1960.
    • e. States Shops & Establishments Act & Rules.
    • f. Insecticides Act 1968.
    • g. AICTE Act 1987.
    • h. Factories Act 1948.
    • i. Minimum Wages Act 1948.
    • j. Patents Act 1970.

    UNIT-IV

    A brief study of the various Prescription/Non-prescription Products, Medical /Surgical accessories, Diagnostic aids, appliances available in the market. Note: The teaching of all the about Acts should cover the latest amendments.

    Books:

    • 1. Jain N.K., A Textbook of Forensic Pharmacy, VallabhPrakashan, N. Delhi.
    • 2. Singh H., History of Pharmacy in India- Vol.-I, II & III, VallabhPrakashan.
    • 3. Mittal B.M., Textbook of Forensic Pharmacy, National Book Centre, Dr. Sundari Mohan Avenue, Calcutta.
    • 4. Relevant Acts & Rules, Published by the Govt. of India.
    04
  • JBP-651

    Pharmaceutical Chemistry–VI (Medicinal Chemistry - I) (P):

    • 1. Exercises based on QSAR: Hansch& Free-Wilson methods.
    • 2. Synthesis of selected drugs from the course content.
    • 3. Spectral analysis of the drugs synthesized.
    • 4. Establishing the pharmacopoeial standards of the drugs synthesized.
    • 5. Determination of partition coefficient, dissociation constant and molar refractivity of compounds for QSAR analysis.
    02
  • JBP-652

    Pharmacology – II (P):

    Experiments on Isolated Preparations:

    • 1. To record the dose response curve of Acetylcholine using ileum of rat.
    • 2. To study the parallel shift of dose response curve in presence of competitive antagonist on doseresponse curve of Ach using rat ileum.
    • 3. To study effect of physostigmine on dose response curve of each on rat ileum.
    • 4. To study the dose response curve of histamine on guinea pig on ileum preparation & study the effect of antihistaminics.
    02
  • JBP-653

    Pharmacognosy–V (Chemistry of Natural Products) (P):

    • 1. Laboratory experiments on isolation, separation, purification of various groups of chemical constituents of pharmaceutical significance.
    • 2. Exercises on paper and thin layer chromatographic evaluations of herbal drug constituents.
    02
  • JBP-654

    Pharmaceutics–VII (Pharmaceutical Technology II) (P):

    • 1. Experiments to illustrate preparation, stabilization, physical and biological evaluation of pharmaceutical products like powders, capsules, tablets, parenterals, micro capsules, surgical dressing etc.
    • 2. Evaluation of materials used in pharmaceutical packaging.
    02
  • Total Credits
     
    28